Monday, November 07, 2011: 04:13:37 PM

Chemical Modification of Biological Polymers

Author: Roger L. Lundblad

Published On: September, 2011

Publisher: CRC Press

Price:  £95.00

Write-up: Summary
Examining the chemical modification of biological polymers and the emerging applications of this technology, Chemical Modification of Biological Polymers reflects the change in emphasis in this subsection of biotechnology from the study of protein structure and function toward applications in therapeutics and diagnostics.


• The basic organic chemistry of the modification proteins, nucleic acids, oligosaccharides, polysaccharides, and their applications
• New analytical technologies used to characterize the chemical modification of biological polymers
• Identification of in vivo, non-enzymatic chemical modification of biological polymers
• Specific chemical modifications to generate biopharmaceutical products


This book covers the basics on the organic chemistry underlying the chemical modification of biopolymers, including updates on the use of various chemical reagents. It describes the current status of chemical modification of biological polymers and emerging applications of this technology in biotechnology. These technologies are important for the manufacture of conjugate proteins used in drug delivery, for the preparation of nucleic acid microarrays, and for the preparation of hydrogels and other materials used in tissue engineering.

Features
• Describes the current status of chemical modifications of biological polymers and the emerging applications of this technology in biotechnology
• Presents in vivo modifications of biological polymers and methods for detecting such modifications
• Covers the uses of chemical modifications for the production of biopharmaceutical products
• Includes material on orthogonal methodology and mass spectrometry

Table of Contents:
• Functional groups in Biological Polymers and Factor Governing Reactivity
• Modification of Amino Groups in Proteins
• Modification of Hydroxyl and Carboxyl Groups in Proteins
• Modification of Imidazole and Indole Groups in Proteins
• Modification of Sulfur-Containing Groups in Proteins
• Modification of Nucleic Acids
• Modification of Polysaccharides
• In Vivo Non-enzymatic chemical modification of biological polymers
• Proteomic Methods for the Analysis of the Modification of Biological Polymers
• Chemical Methods for the Preparation of Conjugates of Biological Polymers


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